Cardiff flanker Ellis Jenkins will start for Wales for the first time in three years as he lines up at flanker against South Africa at the Principality Stadium on Saturday evening.
The 28-year-old adds to his 11-caps won to-date against the same opposition he suffered the serious knee injury that kept him sidelined for just over two years, as a rib injury denied him the opportunity to feature against New Zealand last weekend.
Jenkins is one of six changes to the side that fell to the All Blacks, with Jenkins, who replaces the injured Ross Moriarty, joined in the pack by club teammate Rhys Carre who makes just a fifth international start at loosehead prop as Wyn Jones switches to the replacements. The other change in the pack sees Will Rowlands replace the injured Alun Wyn Jones.
In the backs there is a switch at fly-half where Dan Biggar gets the nod and Gareth Anscombe moves to the replacements, Nick Tompkins is preferred to Johnny Williams in the centre, where Jon Davies takes over the captaincy, and Louis Rees-Zammit comes in for Owen Lane on the wing.
On the bench there are potential first caps for hooker Bradley Roberts and tighthead prop WillGriff John, while Ben Carter is the second row option, and Liam Williams returns to fitness to cover the outside backs.
Wales: Johnny McNicholl, Louis Rees-Zammit, Jon Davies (c), Nick Tompkins, Josh Adams, Dan Biggar, Tomos Williams; Rhys Carre, Ryan Elias, Tomas Francis, Adam Beard, Will Rowlands, Ellis Jenkins, Taine Basham, Aaron Wainwright
Replacements: Bradley Roberts, Wyn Jones, WillGriff John, Ben Carter, Seb Davies, Gareth Davies, Gareth Anscombe, Liam Williams