Wales head coach Wayne Pivac has made five changes to his starting XV that will go for the Triple Crown against England on Saturday, 4.45pm kick-off.
Only one is in the forward pack where Josh Navidi is fit again to take his place on the blindside flank, while the backs sees a big overhaul.
Kieran Hardy gets the nod at scrum-half, while Jon Davies is fit again to start at inside centre. Josh Adams returns from his coronavirus breach suspension to start on the wing, with Liam Williams preferred to Leigh Halfpenny at full-back. Owen Watkin and Nick Tompkins drop out of the matchday 23 altogether.
The final change sees George North fit again to start at outside centre and become the youngest player in the history of the game to win his 100th international cap at the age of 28.
On the bench there is a recall for Cory Hill to cover the second row and Gareth Davies drops down to be the scrum-half option.
Wales: Liam Williams, Louis Rees-Zammit, George North, Jon Davies, Josh Adams, Dan Biggar, Kieran Hardy; Wyn Jones, Ken Owens, Tomas Francis, Adam Beard, Alun Wyn Jones (c), Josh Navidi, Justin Tipuric, Taulupe Faletau
Replacements: Elliot Dee, Rhodri Jones, Leon Brown, Cory Hill, James Botham, Gareth Davies, Callum Sheedy, Willis Halaholo