Wales head coach Wayne Pivac has made four changes to the starting XV that lost to England last week as he aims to finish the Six Nations with a victory over Scotland.
Three of the changes come up front including a new propping duo which sees Wyn Jones return to fitness to reclaim the loosehead position and WillGriff John set to make his debut at tighthead after Dillon Lewis picked up a knock last week.
Then in the second row there is a welcome return for Cory Hill who is back fit for the first time since the Italy game in round one, replacing Jake Ball who has undergone surgery on the right shoulder hurt at Twickenham.
The only change in the backs sees Tomos Williams drops out of the 23 entirely as Rhys Webb starts a first Wales game since November 2017, with Gareth Davies covering scrum-half from the bench.
There is one other change among the replacements as Will Rowlands is back fit to cover second row as Aaron Shingler makes way for him.
Alun Wyn Jones will lead the side as he equals the world record for test caps won, earning cap number 148 as he draws level with Richie McCaw. This will be his 139th Wales cap, added to nine British and Irish Lions tests.
Wales: Leigh Halfpenny, George North, Nick Tompkins, Hadleigh Parkes, Liam Williams, Dan Biggar, Rhys Webb; Wyn Jones, Ken Owens, WillGriff John, Cory Hill, Alun Wyn Jones (c), Ross Moriarty, Justin Tipuric, Josh Navidi
Replacements: Ryan Elias, Rhys Carre, Leon Brown, Will Rowlands, Taulupe Faletau, Gareth Davies, Jarrod Evans, Johnny McNicholl